Ronald Lynch

Ronald Lynch
University of Arizona
ARIBI, Cancer Center, Physiology

Dr. Lynch received a B.S. degree in Chemistry from the University of Miami, and Ph.D. in Physiology and Biophysics from the University of Cincinnati.  He began training in optical imaging and MR spectroscopy of cardiovascular and renal metabolism in 1984 while at the NIH under the direction of Dr. Robert S. Balaban.  In 1987 Dr. Lynch moved to a staff position in the Biomedical Imaging Group and Physiology Department at the University of Massachusetts Medical Center, and in1990 was recruited to the University of Arizona to develop a research program centered on the use and development of microscopic imaging and spectroscopy to study physiological problems.  In 2000, Dr. Lynch was a visiting scientist at the NIH Laboratory of Functional and Molecular Imaging and the Magnetic Resonance Imaging Center with Dr. Alan Koretsky.  Dr. Lynch is currently Chair of the Physiological Sciences Graduate Training Program, a member of the Arizona Cancer Center, Sarver Heart Center and the Graduate Program in Biomedical Engineering, and is co-PI on the NIH supported Biomedical Imaging and Spectroscopy training grant.  As part of his duties in the Cancer Center, Dr. Lynch is director of a Cancer Core Imaging Facility.  Dr Lynch also is the acting director of the Advanced Research Institute for Biomedical Imaging (ARIBI) at the University of Arizona

Current Research: 

Research in the Lynch lab primarily focuses on second messenger signaling in vascular smooth muscle cells and nutrient sensing hypothalamic neurons with emphasis on alterations in signaling that occur during development of diabetes. Alterations in Ca2+ homeostasis and contractility are observed in vascular cells in association with the elevated levels of glucose and insulin that occur during development of type II diabetes. To study these issues, cells isolated from transgenic animals in which specific genes for Ca2+ handling are ablated or over-expressed are utilized as model systems. Analysis of subcellular protein distributions and second messenger signaling is performed in our lab using state of the art image acquisition and analysis approaches which is our second area of expertise. Over the past decade, our lab has been involved in the development of unique microscopic imaging and spectroscopy approaches to study cell and tissue function. As part of this effort, we have developed, with collaborators, methods for targeting specific cell types in mice for in situ identification and rapid isolation. Using this approach, analysis of cell-type specific gene expression and function can be performed.